Hepatitis is a general term that refers to inflammation (swelling) of the liver. This inflammation can affect several important liver functions and lead to a wide range of uncomfortable symptoms in some people. Even worse, some types of hepatitis can progress to much more serious complications such as cirrhosis, liver cancer and ever death, if not treated early.
Excessive alcohol consumption, certain medications and autoimmune diseases can cause hepatitis but at the root of most cases are viruses (viral hepatitis). Viral hepatitis is most commonly caused by Hepatitis A, B, and C viruses. And while these viruses all lead to liver disease, they vary in important ways.
In this article, we will look at the differences of the 3 most common types of viral hepatitis. By understanding these differences, you can take steps to protect yourself and others from any of these viruses, recognize symptoms and seek medical treatment if necessary.
Understanding the differences of the most common types of Viral Hepatitis:
Hepatitis A | Hepatitis B |
Hepatitis C |
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What is the cause? | Hepatitis A virus (HAV) that is present in the blood and feces (stool) of an infected person. | Hepatitis B virus (HBV) that is present in the blood and certain bodily fluids of an infected person. | Hepatitis C virus (HCV) that is present in the blood and certain bodily fluids of an infected person. |
How do you get infected? |
You may get infected with hepatitis A primarily by ingesting food or water that is contaminated with the feces of an infected person – even in very small amounts. Close person-to-person or sexual contact with an infected person can also be a mode of transmission. |
You can get infected when the HBV virus present in the blood, semen, or other bodily fluid of the infected person gets inside your body. This can commonly happen in the following ways:
Less common modes of transmission include needlestick/sharp injuries and contact with open sores of the infected person. |
You can get infected when the HCV virus present in the blood of the infected person gets inside your body mainly by sharing contaminated needles or syringes with an infected person for illicit drug use. Other less common modes of transmission include sexual contact with infected person, needlestick/sharp injuries and mother-to-child transmission. |
How long does it last? |
Almost all cases of hepatitis A are acute (short-term). Acute infections last only a few weeks to several months (less than 6 months). In acute cases, the immune system is able to successfully fight off the infection, so the virus is cleared from the body and the liver heals completely within 6 months. |
Hepatitis B can also begin as acute infections. However, in some people, the virus remains in the body and causes chronic, or long-lasting, infection that persists for more than 6 months. Chronic HBV infections that are left untreated for several years may lead to serious complications such as, cirrhosis (severe scarring of the liver), liver cancer and liver failure. According to the Centers for Disease Control and Prevention (CDC), chronic HBV infection is common in:
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Hepatitis C can also begin as acute infections. However, in some people, the virus remains in the body and causes chronic, or long-lasting, infection that persists for more than 6 months. Chronic HCV infections that are left untreated for several years may lead to serious complications such as, cirrhosis (severe scarring of the liver), liver cancer and liver failure. More than 50 % (more than 5 out of 10) people infected with HCV will develop chronic (long-lasting) infection. |
How serious is it? |
Since hepatitis A only causes a short-term infection, most infected people recover without permanent liver damage. While most patients infected with hepatitis A recover fully, some people, typically those with pre-existing liver disease, experience severe liver damage that can be fatal. |
15-25 % of people with chronic HBV infection will develop complications such as cirrhosis, liver cancer, or liver failure. |
5-25 % of people with chronic HCV infection will develop cirrhosis in 10-20 years if left untreated. People who developed cirrhosis has 1-4% annual risk of liver cancer. |
How can it be treated? |
There is no medication or specific medical treatment for hepatitis A. Since it is a short-term viral infection that goes away on its own, the focus of treatment will be on supportive methods. You will be advised to have adequate rest, drink lot of fluids, eat a healthy diet and avoid alcohol. |
For acute HBV infection, the treatment is also mostly supportive in the form of adequate rest, hydration, and balanced diet. For chronic infection: Antiviral drugs may be prescribed to control the infection and reduce inflammation and liver damage. Regular monitoring for signs of liver disease progression will also be prescribed. |
A course of antiviral therapy that involve 8-12 weeks of oral medication is prescribed to both acute and chronic infections. It is estimated that over 90 % of people prescribed with antiviral therapy can be cleared of the virus. |
How to prevent infection? |
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There is currently no vaccine available against hepatitis C infection. Instead, you must do the following to prevent contracting the virus:
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Hepatitis A, B and C cause similar symptoms, but not everyone infected will experience it. If symptoms do occur during the acute phase, you may experience any or all the following between two weeks and six months following exposure:
- Fever
- Fatigue
- Loss of appetite
- Nausea
- Vomiting
- Abdominal pain
- Dark-colored urine
- Light-colored stool
- Joint pain
- Jaundice (yellowing of the skin and white portion of the eyes)
With chronic (long-lasting) hepatitis, these symptoms can take decades to develop. By the time symptoms start to appear after several years, it is often a sign of advanced liver disease already.
In summary:
Hepatitis A, hepatitis B, and hepatitis C are liver infections caused by three different viruses. Although each can cause similar symptoms, they have different modes of transmission and affect the liver differently. Hepatitis A is usually an acute infection that resolves within 6 months. On the other hand, both hepatitis B and hepatitis C can start as acute infection but may lead to chronic infection in some people. Chronic hepatitis B and C infections can cause serious complications liver failure, cirrhosis and liver cancer if left untreated.
Many patients with HBV and HCV are usually not aware that they are infected because majority do not have symptoms until they have developed complications such cirrhosis or liver cancer. For this reason, it is important to get screened for HBV and HCV especially if you are exposed to the risk factors mentioned above. This will help you get early diagnosis and timely and appropriate treatment to prevent complications and improve outcomes. Ask your doctor for the possible screening tests that you may take.
The best protection against hepatitis A and B is vaccination but everyone still needs to be vigilant by being responsible in hygiene, sanitation, and interaction with people. For hepatitis C, there is no vaccine available, and the prevention of infection is directed towards reducing the risk of exposure to the virus.
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References:
- https://www.who.int/news-room/questions-and-answers/item/hepatitis
- https://www.cdc.gov/hepatitis/abc/index.htm
- https://www.hepb.org/what-is-hepatitis-b/what-is-hepb/acute-vs-chronic/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070280/
- https://www.cdc.gov/hepatitis/hcv/hcvfaq.htm
- https://www.sfcdcp.org/infectious-diseases-a-to-z/hepatitis-b/